PreDictor MabSelect VL Filter Plates, 50 µL (17542032) are 96-well filter plates prefilled with MabSelect VL protein L chromatography resin for affinity capture of antibody variants containing a kappa light chain. Supplied as 4 x 96-well filter plates, each well contains a defined 50 µL volume of MabSelect VL resin for high-throughput process development and parallel screening of binding, wash, and elution conditions.
Key Features
- Prefilled 96-well filter plate format, supplied as 4 x 96-well plates for high-throughput chromatography condition screening
- Defined 50 µL resin volume per well, supporting small-scale evaluation of MabSelect VL protein L resin conditions
- Designed for antibody variants, supporting capture of antibody Fabs, bispecific antibodies, and other variants containing a kappa light chain
- Alkaline-stabilised protein L-derived ligand, recombinantly produced in E. coli and engineered for improved alkaline stability
- High dynamic binding capacity, specified for the MabSelect VL resin at approximately 60 mg IgGκ1/mL resin at 4 minutes residence time and 70 mg IgGκ1/mL resin at 6 minutes residence time
- Rigid agarose base matrix, using highly cross-linked agarose with an approximate 60 µm median particle size
- High-throughput process development support, enabling parallel screening of chromatographic conditions in a 96-well plate format
- Improved alkaline tolerance, with MabSelect VL resin suitable for cleaning with 0.1 M sodium hydroxide
Benefits
- Helps evaluate binding, wash, and elution conditions quickly using less sample and buffer than larger packed-column screening.
- Supports process development for antibody variants that contain a kappa light chain and may not be suited to protein A capture.
- Allows parallel testing of chromatographic conditions to support faster resin and method optimisation.
- Provides a convenient bridge between resin screening and further optimisation using PreDictor RoboColumn, HiTrap, HiScreen, or bulk MabSelect VL formats.
- Supports robust development work where high binding capacity and alkaline cleaning stability are important selection criteria.
Why Choose the PreDictor MabSelect VL Filter Plates, 50 µL (17542032)?
PreDictor MabSelect VL Filter Plates, 50 µL (17542032) provide a verified Cytiva high-throughput screening format for MabSelect VL protein L affinity capture of antibody Fabs, bispecific antibodies, and other kappa light chain-containing variants. John Morris Group supplies chromatography consumables and process development tools for Australian laboratories working across antibody purification and bioprocess optimisation workflows.
