The Capto Adhere Multimodal Resin, 100 mL (17544401) is a multimodal BioProcess chromatography resin for post-protein A purification of monoclonal antibodies at process scale. It uses a strong anion exchange multimodal ligand on a highly cross-linked agarose matrix to help remove key impurities such as DNA, host cell proteins, leached protein A, aggregates and viruses.
Key Features
- Bulk resin format, supplied as a 100 mL pack for process development, scale-down studies and flexible column packing
- Multimodal strong anion exchange functionality, giving different selectivity compared with traditional ion exchangers
- Post-protein A mAb purification design, intended for intermediate purification and polishing after protein A capture
- Highly cross-linked agarose matrix, providing a rigid spherical base for high-flow packed-bed chromatography
- Approximate 75 µm median particle size, supporting efficient flow-through operation and impurity removal
- Ionic capacity of 0.09 to 0.12 mmol Cl-/mL resin, supporting multimodal anion exchange performance
- Pressure-flow performance of at least 600 cm/h, measured at ≤0.3 MPa in a 1 m diameter column with 20 cm bed height
- Operational pH stability from 3 to 12, with CIP pH stability from 2 to 14
Benefits
- Supports efficient post-protein A polishing by allowing monomeric mAbs to pass through while key impurities bind to the resin.
- Helps simplify downstream mAb purification by enabling a two-step chromatographic process with a protein A capture step.
- Supports high capacity and productivity for process-scale monoclonal antibody workflows.
- Provides a wide operational window for pH and conductivity screening during method development.
- Withstands standard cleaning procedures, including 1.0 M NaOH, 2 M NaCl or 70% ethanol.
Why Choose the Capto Adhere Multimodal Resin, 100 mL (17544401)?
The Capto Adhere Multimodal Resin, 100 mL (17544401) gives Australian laboratories and bioprocess teams a flexible pack size for evaluating post-protein A mAb polishing with Capto adhere resin. John Morris Group supplies Cytiva chromatography products with local support to help match resin chemistry, pack size and purification workflow to your application.
