CEM Fmoc-Trp(Boc)-OH is a high-purity amino acid for peptide synthesis, designed for use with ProTide™ resins featuring an optimized PEG and polystyrene core. These resins enable rapid and efficient loading of amino acids, creating an ideal environment for the synthesis of difficult peptides with excellent swelling properties. Compatible with automated microwave peptide synthesizers for fast, reproducible results.
Product Features
- High-purity amino acid: Nα-Fmoc-N(in)-Boc-tryptophan (Fmoc-Trp(Boc)-OH), 2.5mmol, 5 pack
- Compatible with ProTide™ resins with optimized PEG and polystyrene core
- New Cl-TCP(Cl) and Cl-MPA linkers allow loading without pre-loaded C-terminal amino acids
- Automated, high-temperature loading on Liberty Blue microwave peptide synthesizer in 10 minutes (room temperature takes up to 24 hours)
- Avoids coupling reagents, minimizing epimerization and dipeptide formation
- No need to buy/store >20 different pre-loaded acid-linked resins
- Exhibits strong stability toward hydrolysis during storage and handling
- TCP(Cl) is hyperacid sensitive, enabling protected peptides with 1% TFA/DCM
- Minimizes diketopiperazine and 3-(1-piperidinyl)alanine formation
- References: Sandhya K., Ravindranath B., Tetrahedron Lett. 49, 2435 2008; Heinlein C., Silva D., Tröster A., Angew. Chem. 50, 6406 2011
Key Advantages
- Automated, high-temperature loading procedure completes in 10 minutes (vs. up to 24 hours at room temperature)
- Eliminates coupling reagents, reducing epimerization and dipeptide formation
- No need to buy or store multiple pre-loaded acid-linked resins
- Strong stability toward hydrolysis during storage and handling
- Minimizes side reactions such as diketopiperazine and 3-(1-piperidinyl)alanine formation
Benefits
- Rapid amino acid loading ensures high efficiency in peptide synthesis
- Reduces side reactions common in conventional loading methods
- Stable and reliable product for long-term laboratory use
- Supports automated peptide synthesis with consistent high-quality results
Why Choose CEM Fmoc-Trp(Boc)-OH, Amino Acid, 2.5mmol, 5 Pack?
This amino acid provides a reliable solution for peptide synthesis, offering fast, stable, and efficient loading on ProTide™ resins while reducing side reactions and improving overall workflow in automated peptide synthesis.
