The MabSelect PrismA X Protein A Resin, 200 mL (17550102), is a bulk Protein A affinity chromatography resin designed for efficient capture of monoclonal antibodies. It combines high dynamic binding capacity with exceptional alkaline stability, helping support robust cleaning-in-place workflows and cost-efficient mAb capture.
Key Features
- Bulk 200 mL resin format, supplied for packing into suitable chromatography columns
- High-capacity Protein A resin, designed for efficient monoclonal antibody capture workflows
- Highly cross-linked agarose matrix, supplied as spherical resin beads for packed-bed chromatography
- 50 µm median particle size, supporting strong mass transfer and suitability for short bed height applications
- Alkali-stable protein A-derived ligand, produced in E. coli and attached by single-point coupling
- High dynamic binding capacity, with more than 80 mg mAb/mL resin at 6 min residence time and more than 74 mg mAb/mL resin at 4 min residence time
- Defined operating flow velocity, with recommended maximums of 220 cm/h at 20 cm bed height and 400 cm/h at 10 cm bed height
- Excellent CIP stability, compatible with 0.5 to 1.0 M sodium hydroxide for repeated cleaning-in-place workflows
Benefits
- Helps increase mass throughput of processed monoclonal antibody per resin volume.
- Supports robust cleaning and sanitisation to help reduce bioburden risk between purification cycles.
- Can help reduce resin and buffer consumption in antibody capture processes.
- Supports short bed height and rapid cycling chromatography approaches for improved capture-step productivity.
- Provides a scalable resin format for process development through to clinical and commercial mAb production workflows.
Why Choose the MabSelect PrismA X Protein A Resin, 200 mL (17550102)?
The MabSelect PrismA X Protein A Resin, 200 mL (17550102), is suited to laboratories and bioprocess teams requiring high binding capacity, strong alkaline stability, and robust Protein A capture performance. John Morris Group supplies Cytiva chromatography resins across Australia, helping customers select suitable affinity media for downstream purification and process development workflows.
