The Capto L Antibody Fragment Purification Resin, 5 mL (17547806) is an affinity chromatography resin for capture of antibodies and antibody fragments. It uses a recombinant Protein L ligand with strong affinity for the variable region of antibody kappa light chains, making it suitable for fragments such as Fabs, scFv and domain antibodies.
Key Features
- Bulk resin format, supplied as a 5 mL pack for small-scale column packing, screening and method development
- Protein L affinity chemistry, using a recombinant Protein L ligand produced in E. coli
- Kappa light-chain selectivity, binding to the variable region of antibody kappa light chains
- Rigid highly cross-linked agarose matrix, supporting high-flow affinity chromatography workflows
- 85 µm average particle size, providing a process-suitable resin bead format
- Approx. 25 mg Fab/mL resin dynamic binding capacity, measured at 10% breakthrough under stated test conditions
- Maximum flow velocity of 500 cm/h, based on a 20 cm bed height
- Working pH stability from 2 to 10, with cleaning-in-place using 15 mM NaOH
Benefits
- Supports efficient capture of antibody fragments that contain kappa light chains.
- Helps purify a broad range of antibody fragment formats, including Fabs, scFv and domain antibodies.
- Provides high-flow performance to support productivity and process design flexibility.
- Uses epoxy-based coupling chemistry to support low ligand leakage during purification.
- Offers a convenient 5 mL pack size for early method development before moving to larger resin or prepacked formats.
Why Choose the Capto L Antibody Fragment Purification Resin, 5 mL (17547806)?
The Capto L Antibody Fragment Purification Resin, 5 mL (17547806) gives Australian laboratories a compact resin format for developing Protein L affinity purification of antibody fragments with kappa light chains. John Morris Group supplies Cytiva chromatography products with local support to help match resin chemistry, pack size and purification workflow to your application.
