The MabSelect SuRe LX Protein A Resin, 25 mL (17547401), is a bulk protein A affinity chromatography resin developed for processing monoclonal antibodies at high titers. It combines high dynamic binding capacity at extended residence times with alkali-stabilised protein A ligand chemistry for robust mAb capture workflows.
Key Features
- Bulk resin format, supplied as 25 mL for packing into suitable chromatography columns
- High dynamic binding capacity, with approximately 60 mg human IgG/mL medium at 6 min residence time
- Alkali-stabilised protein A ligand, derived from E. coli for monoclonal antibody capture
- Single-point ligand attachment, using epoxy coupling chemistry for stable ligand immobilisation
- Rigid highly cross-linked agarose matrix, supporting high-flow packed-bed chromatography
- 85 µm average particle size, based on d50v median particle size of the cumulative volume distribution
- High mobile phase velocity, with a maximum mobile phase velocity of 500 cm/h under Cytiva test conditions
- Alkaline CIP compatibility, with cleaning-in-place stability in 0.1 to 0.5 M NaOH
Benefits
- Supports efficient capture of monoclonal antibodies from high-titer feed streams.
- Helps reduce resin volume or processing time where higher dynamic binding capacity is required.
- Enables sodium hydroxide cleaning-in-place to support robust resin reuse workflows.
- Provides a bulk resin format for method development, packing studies and scale-up planning.
- Supports platform mAb purification workflows using protein A affinity capture.
Why Choose the MabSelect SuRe LX Protein A Resin, 25 mL (17547401)?
Choose the MabSelect SuRe LX Protein A Resin, 25 mL (17547401), when you need a high-DBC protein A resin for high-titer monoclonal antibody capture and process development. John Morris Group supplies Cytiva chromatography products to Australian laboratories with local support for selection and ordering.
