The MabSelect SuRe 70 Protein A Resin, 25 mL (17542401) is an affinity chromatography resin for cost-efficient capture of monoclonal antibodies. It combines high dynamic binding capacity, an alkali-stable protein A-derived ligand and a 50 µm high-flow agarose matrix for antibody capture workflows where productivity and resin utilisation are important.
Key Features
- 25 mL bulk resin format, supplied for packing into suitable chromatography columns during method development or process work
- High dynamic binding capacity, with greater than 70 mg mAb/mL resin at 6 min residence time and greater than 65 mg mAb/mL resin at 4 min residence time
- Highly cross-linked agarose matrix, spherical and designed for protein A affinity chromatography applications
- 50 µm median particle size, supporting high-flow operation and fast mAb uptake
- Alkali-stable protein A-derived ligand, derived from E. coli and attached by single-point coupling
- Epoxy coupling chemistry, used for ligand attachment to the resin matrix
- Short bed height flow capability, with recommended maximum operating flow velocity of 220 cm/h at 20 cm bed height and 400 cm/h at 10 cm bed height
- Broad cleaning and operating window, with operational pH stability of 3 to 12 and CIP pH stability of 2 to 13.7
Benefits
- Helps improve capture-step productivity by maintaining high mAb binding capacity at practical residence times.
- Supports cost-efficient use in lower resin-utilisation scenarios, including clinical manufacturing where fewer batch runs may be required.
- Enables rapid resin cycling and short bed height strategies for higher throughput protein A capture workflows.
- Provides alkaline cleaning tolerance for robust processing and reduced bioburden risk during repeated use.
Why Choose the MabSelect SuRe 70 Protein A Resin, 25 mL (17542401)?
Choose the MabSelect SuRe 70 Protein A Resin, 25 mL (17542401) when you need a high-DBC protein A resin for monoclonal antibody capture with strong alkaline cleaning stability. John Morris Group supplies Cytiva chromatography consumables for Australian laboratories and can help confirm suitability for your antibody purification workflow.
