CEM Rink Amide ProTide Resin 1 g features an optimized PEG resin core combined with advanced Cl-TCP(Cl) and Cl-MPA universal linkers. This design provides an ideal environment for the synthesis of difficult peptides with excellent swelling properties. The resin eliminates the need for pre-loaded C-terminal amino acid resins, enabling fast and efficient direct loading in minutes.
Product Features
- Optimized PEG and polystyrene core ensures superior swelling properties for efficient peptide synthesis.
- Cl-TCP(Cl) and Cl-MPA universal linkers eliminate the need for pre-loaded C-terminal amino acid resins.
- Enables direct reaction of C-terminal amino acids with linker-chloride using potassium iodide (KI), N,N-diisopropylethylamine (DIEA), and microwave irradiation.
- Supports automated loading on Liberty Blue microwave peptide synthesizers with pre-programmed software methods.
- High-temperature loading completed in just 10 minutes (compared to up to 24 hours at room temperature).
- Avoids coupling reagents, minimizing epimerization and dipeptide formation during loading.
- Reduces the need to maintain large inventories of multiple pre-loaded acid-linked resins.
- Exhibits strong hydrolysis stability during storage and handling.
- TCP(Cl) hyperacid sensitivity enables protected peptide production with 1% TFA/DCM, minimizing diketopiperazine and 3-(1-piperidinyl)alanine formation.
- Recommended for peptides with amide linkages under 30 amino acids.
- PEG PS core with a loading capacity of 0.6 – 0.8 mmol/g.
- Technical References: Sandhya K., Ravindranath B. Tetrahedron Lett. 49, 2435 (2008); Heinlein C., Silva D., Tröster A., Schmidt J., Gross A., Unverzagt C. Angew. Chem. 50, 6406 (2011).
Key Advantages
- Automated, high-temperature loading in just 10 minutes for improved efficiency.
- Minimizes side reactions such as epimerization and diketopiperazine formation.
- Streamlines resin inventory by removing the need for multiple pre-loaded resins.
- Exceptional stability during storage and handling.
- Ideal for synthesis of short to mid-length peptide amides.
Benefits
- Enables fast and efficient peptide synthesis workflows.
- Ensures high purity and reproducibility of synthesized peptides.
- Reduces costs and storage space requirements.
- Ideal for routine and research laboratory peptide synthesis.
Why Choose CEM Rink Amide ProTide Resin 1 g?
This resin is a powerful and efficient solution for amide peptide synthesis, providing unmatched speed, minimized side reactions, and reliable performance—perfect for sequences under 30 amino acids.
