JMG No: 1234844
Part No: S001-D
Availability: Within 50 days
OxymaPure® used with DIC produces peptides with increased yield and decreased epimerization when used as an alternative to HOBt1 . This safe, non-explosive auxiliary nucleophile works with carbodiimide coupling strategies to provide the best results for a peptide synthesis. Additionally, the use of DIC/Oxyma avoids side reactions associated with high levels of base (≥ 1 equiv. DIEA) using onium salt methods such as HBTU/DIEA.
1R. Subirós-Funosas, et al. (2009) Chem. Eur. J., 15, 9394.
- Extremely fast acylation rates
- Non-explosive (compared to HOBt)
- Low cost
- Highly soluble in peptide synthesis solvents